The effects of ionic strength and temperature on the dissociation constants of adefovir and cidofovir used as antiviral drugs
Yazarlar (2)
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Hayati SARI
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Turkish Journal of Chemistry |
| Dergi ISSN | 1300-0527 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2014 |
| Cilt No | 38 |
| Sayı | 5 |
| Sayfalar | 806 / 814 |
| DOI Numarası | 10.3906/kim-1309-39 |
| Makale Linki | http://journals.tubitak.gov.tr/chem/issues/kim-14-38-5/kim-38-5-12-1309-39.pdf |
| Özet |
| The effects of ionic strength and temperature on the dissociation constants of adefovir (PMEA) and cidofovir (HPMPC) used as antiviral drugs were studied at 298 K, 308 K, and 318 K in aqueous media and at different ionic strength backgrounds of NaCl potentiometrically. The dissociation constants of the ligands were determined via the calculation of the titration data with the SUPERQUAD computer program. The thermodynamic parameters ( ∆G , ∆H , and ∆S) for all species were calculated. The dissociation order of nitrogen and oxygen atoms in the ligands according to proton affinities values were obtained using PM6 semiempirical methods. Moreover, p Ka values of the −3ligands were determined at 0.00, 0.10, 0.15, 0.20, and 0.5 mol dm ionic strength (NaCl) at 298 K. Consequently, when the ionic strength and temperature in the titration cells were increased, the obtained dissociation constants of PMEA (p Ka3 , p Ka4 , and p Ka5 ) and HPMPC (p Ka2 and p Ka3 ) decreased. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| TRDizin | 1 |