Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behçet’s disease
Yazarlar (6)
Hitit Üniversitesi, Türkiye
Prof. Dr. Helin DENİZ DEMİR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Osman DEMİR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | European Journal of Rheumatology |
| Dergi ISSN | 2147-9720 Wos Dergi |
| Dergi Tarandığı Indeksler | ESCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2018 |
| Cilt No | 5 |
| Sayı | 1 |
| Sayfalar | 27 / 31 |
| DOI Numarası | 10.5152/eurjrheum.2017.16102 |
| Makale Linki | http://www.eurjrheumatol.org/eng/makale/3059/213/Full-Text |
| Özet |
| Objective: Behçet’s disease (BD), a chronic multisystem inflammatory disorder, is mainly characterizedby relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play importantroles in the pathogenesis of BD. Therefore, interleukin-1 receptor antagonist (IL-1Ra) gene 86bp variablenumber tandem repeat (VNTR) variant was investigated in patients with BD in a Turkish population.Methods: One hundred nine patients (60 females, 49 males; the mean age±standard deviation [SD]was 36.56±9.571 years) with BD and one hundred healthy individuals (54 females, 46 males; the meanage±SD was 36.64±2.294 years) were examined in the study. For genotyping, polymerase chain re-action-restriction fragment length polymorphism analysis was employed. Data were analyzed usingStatistical Package for Social Sciences (SPSS) 22.0 (IBM Corp.; Armonk, NY, USA) (p<0.05)Results: The genotype distribution and allele frequencies of the IL-1Ra VNTR variant did not differsignificantly between the patients and the controls (p>0.05). The frequency of the a1/a1, a1/a2 geno-types and a1, a2 alleles were the most common both in patients and healthy controls (p=0.37, p=0.26,and p=0.53, respectively). Also, no statistically significant difference was found between the IL-1RaVNTR variant genotypes and clinical characteristics (p>0.05).Conclusion: The results of this study do not support an association between the IL-1Ra VNTR variantand the risk of BD in a Turkish population. However, further studies of this variant with larger samplesizes and different ethnicities are required for confirmation. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |