Synthesis, characterization and anti-tumor activity of Pd(II) complexes with 4,5-benzo-3H-1,2-dithiole-3-thione
Yazarlar (6)
Tikrit University, Irak
Tikrit University, Irak
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
T.C. Sağlık Bakanlığı,, Türkiye
Doç. Dr. Hüseyin AKBAŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Universidad Rey Juan Carlos, İspanya
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Transition Metal Chemistry |
| Dergi ISSN | 0340-4285 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2019 |
| Cilt No | 44 |
| Sayı | 6 |
| Sayfalar | 575 / 583 |
| DOI Numarası | 10.1007/s11243-019-00314-6 |
| Makale Linki | https://doi.org/10.1007/s11243-019-00314-6 |
| Özet |
| Abstract: Reaction of Na2[PdCl4] with two equivalents of 4,5-benzo-3H-1,2-dithiole-3-thione (btt) affords cis-[PdCl2(κ1-btt)2] (1), which provides a convenient entry into mixed-ligand btt complexes. Addition of one equivalent of a range of diamines or diphosphines gives the salts [Pd(κ1-btt)2(κ2-diamine)]Cl2 (2a–d) (diamine = en, dap, bipy, phen) and [Pd(btt)2(κ2-diphosphine)]Cl2 (3a–c) (diphosphine = dppe, dppp, dppf) in good yields. In contrast, two equivalents of dppm result in [Pd(κ1-btt)2(κ1-dppm)2]Cl2 (4), where the diphosphine binds in a monodentate fashion. Two equivalents of PPh3 result in a mixture of cis- and trans-isomers of [Pd(κ1-btt)2(PPh3)2]Cl2 (5a–b) (ca. 1:5 ratio); the pure trans-isomer 5b was isolated by ion-exchange chromatography. The cis-isomer 5a could be synthesized independently from the reaction of cis-[PdCl2(PPh3)2] with two equivalents of btt. In all of these complexes, the btt ligand binds in a monodentate manner through the exocyclic thione sulfur. The anti-tumor activities of representative examples, cis-[PdCl2(κ1-btt)2] (1), cis-[Pd(κ1-btt)2(κ1-dppm)2]Cl2 (4) and cis-[Pd(κ1-btt)2(PPh3)2] (5a), were evaluated by cell proliferation assays and phase-contrast microscopy against prostate cancer cell lines PC3, DU145 and LNCaP, with complexes 1 and 4 showing potent anti-proliferative effects (TGI values of 19.2 and 21.1 µg/mL, respectively) against LnCaP cells. Graphical abstract: [Figure not available: see fulltext.]. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 40 |
| SCOPUS | 55 |