Bioactivity–guided isolation of flavonoids from Cynanchum acutum L. subsp. sibiricum (willd.) Rech. f. and investigation of their antiproliferative activity
Yazarlar (5)
Doç. Dr. İlyas YILDIZ
Iğdır Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ramazan ERENLER
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Iğdır Üniversitesi, Türkiye
Bingöl Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Natural Product Research |
| Dergi ISSN | 1478-6419 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2017 |
| Cilt No | 31 |
| Sayı | 22 |
| Sayfalar | 2629 / 2633 |
| DOI Numarası | 10.1080/14786419.2017.1289201 |
| Makale Linki | http://dx.doi.org/10.1080/14786419.2017.1289201 |
| Özet |
| Cynanchum acutum L. subsp. sibiricum (Willd.) Rech. f. was extracted with hexane, acetone, methanol and water individually. A sample was heated in water then extracted with ethyl acetate. Among the extracts, the ethyl acetate extract exhibited the most antiproliferative activity, so isolation of bioactive compounds was carried out from this extract. A new compound, kaempferol-3-O-β-xylopyranosyl-(1-2)-β-rhamnopyranoside (1) along with five known compounds, quercetin-3-O-β-xyloside (2), kaempferol-3-O-β-glucoside (3), quercetin-3-O-β-glucoside (4), kaempferol-3-O-β-rhamnopyranoside (5), and kaempferol-3-O-β-d-neohesperidoside (6) were isolated from ethyl acetate extract. The structures were elucidated by spectroscopic techniques, basically 1D NMR, 2D NMR and LC-TOF/MS. Antiproliferative effects of isolated compounds were determined by xCELLigence using the HeLa (human uterus carcinoma) cell lines. Compound 2 and compound 5 revealed the good antiproliferative activity against HeLa cell lines. |
| Anahtar Kelimeler |
| antiproliferative activity | Cynanchum acutum subsp. sibiricum | flavonoids |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 28 |
| SCOPUS | 28 |
| Google Scholar | 37 |