Potentiometric PVC Membrane Sensor for the Determination of Anti-Epileptic Drug Levetiracetam in Pharmaceutical Formulations
Yazarlar (2)
Doç. Dr. Oğuz ÖZBEK
Zonguldak Bülent Ecevit Üniversitesi, Türkiye
Prof. Dr. Ömer IŞILDAK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Chemistryselect |
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2022 |
| Cilt No | 7 |
| Sayı | 3 |
| Sayfalar | 202103988 / 0 |
| DOI Numarası | 10.1002/slct.202103988 |
| Makale Linki | https://doi.org/10.1002/slct.202103988 |
| Özet |
| A poly(vinyl chloride) (PVC) membrane potentiometric sensor was developed for the determination of anti-epileptic drug levetiracetam. For this purpose, levetiracetam-tetraphenylborate (LEV-TPB) ion-pair was synthesized and the synthesized ion-pair was used as ionophore in PVC membrane structures. The membrane composed of 3.0 % (w/w) LEV-TPB ion-pair, 32.0 % (w/w) PVC, and 65.0 % (w/w) o-nitrophenyloctylether (o-NPOE) was determined as the membrane with the best potentiometric properties. The developed sensor exhibited a linear response in the concentration range from 1.0×10−5 to 1.0×10−1 mol L−1 and had a detection limit of 6.31×10−6 mol L−1. For this sensor, pH working range and response time were determined as 6.0–8.0 and ≈25 s, respectively. The sensor displayed a good selectivity for levetiracetam in the presence of a number of common ionic species and some anti-epileptic drug. The proposed levetiracetam-selective sensor was successfully applied for the determination of levetiracetam in pharmaceutical drug samples which is used in the treatment of epilepsy. |
| Anahtar Kelimeler |
| Anti-epileptic | ion pair | levetiracetam | potentiometry | sensors |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 21 |
| SCOPUS | 24 |
| Google Scholar | 30 |