Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus
Yazarlar (10)
Sinan Saral Recep Tayyip Erdogan University, Türkiye
Atilla Topçu Recep Tayyip Erdoğan Üniversitesi, Türkiye
Mehmet Alkanat Giresun Üniversitesi, Türkiye
Tolga Mercantepe Recep Tayyip Erdoğan Üniversitesi, Türkiye
Zafer Şahin Karadeniz Teknik Üniversitesi Tip Fakültesi, Türkiye
Kerimali Akyıldız Recep Tayyip Erdogan University, Türkiye
Kader Semra Karataş Kütahya University Of Health Sciences, Türkiye
Dr. Öğr. Üyesi Lamiye YILDIZ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Levent Tümkaya Recep Tayyip Erdogan University, Türkiye
Zihni Açar Yazıcı Recep Tayyip Erdogan University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Chemical Neuroanatomy (Q3) | ||
| Dergi ISSN | 0891-0618 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2023 |
| Cilt / Sayı / Sayfa | 130 / 1 / 1–11 | DOI | 10.1016/j.jchemneu.2023.102269 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S089106182300039X?via%3Dihub | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
|
||
| Özet |
| Cisplatin is a drug used effectively in the treatment of malignant tumors. However, cisplatin has many side effects, including cognitive impairment. Agomelatine, a synthetic melatonin analogue, is an important antidepressant. Increasing evidence has shown that agomelatine may be a potential neuroprotective agent. The aim of this study was to investigate the effect of agomelatine on learning and memory functions in cisplatin-induced cognitive impairment in a rat model. Male rats were administered agomelatine and cisplatin for 4 weeks. Neurobehavioral tests were performed at the end of the 4th week. After behavioral tests, rats were euthanized and BDNF, TNF, IL-1β, MDA and GSH levels were measured in hippocampal homegenates by ELISA. In addition, nNOS and TrkB receptor activity were measured immunohistochemically. The results showed that agomelatine significantly improved cognitive functions in ... |
| Anahtar Kelimeler |
| Agomelatine | BDNF | Cisplatin | Memory | nNOS |
Science Direct
Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 8 |
| Web of Science | 15 |
| Scopus | 16 |
| Google Scholar | 18 |