The effect of white tea on serum TNF-α/NF-κB and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats
Yazarlar (9)
Sinan Saral Recep Tayyip Erdogan University, Türkiye
Eda Dokumacioglu Artvin Coruh University, Türkiye
Tolga Mercantepe Recep Tayyip Erdogan University, Türkiye
Mehtap Atak Recep Tayyip Erdogan University, Türkiye
Seda Cinar Recep Tayyip Erdogan University, Türkiye
Ozlem Saral Recep Tayyip Erdogan University, Türkiye
Dr. Öğr. Üyesi Lamiye YILDIZ Recep Tayyip Erdogan University, Türkiye
Hatice Iskender Artvin Coruh University, Türkiye
Levent Tumkaya Recep Tayyip Erdogan University, Türkiye
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Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Biomedicine and Pharmacotherapy (Q1) | ||
| Dergi ISSN | 0753-3322 Dergi Bilgileri (2019) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2019 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-04-2019 |
| Cilt / Sayı / Sayfa | 112 / 1 / 10–17 | DOI | 10.1016/j.biopha.2019.108604 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0753332218377837?via%3Dihub | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| ObjectiveNephrotoxicity is the most important side effect of the antineoplastic drug cisplatin, thereby restricting its use. The aim of this study was to investigate the protective effects of white tea infusions (WT) against renal damage induced by cisplatin (CP) in rats by biochemical and histopathological means.Materials and methodsThis study used 24 female Sprague Dawley rats at 12–14 weeks of age and weighing 250–300 g. Rats were divided into three groups: Control, CP and CP + WT groups. CP was injected 7 mg/kg i.p as a single dose/rat in the CP group. White tea was given at a dose of 0.5% (w/v) for 4 weeks. At the end of the experiment, blood urea nitrogen (BUN), creatinine, uric acid, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and nuclear factor kappa B (NF-κB) along with caspase-3 in the kidney were evaluated in study.ResultsBUN, creatinine, TNF-α, NF-κB and IL-6 levels of the CP … |
| Anahtar Kelimeler |
| Caspase-3 | Cisplatin | NF-κB | Renal damage | tea | TNF-α |
Science Direct
The effect of white tea on serum TNF-α/NF-κB and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 7 |
| Web of Science | 20 |
| Scopus | 25 |
| Google Scholar | 31 |