Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction To be published in: Behavioural Brain Research.
Yazarlar (9)
Sinan Saral Recep Tayyip Erdogan University, Türkiye
Atilla Topcu Recep Tayyip Erdogan University, Türkiye
Mehmet Alkanat Giresun Üniversitesi, Türkiye
Tolga Mercantepe Recep Tayyip Erdogan University, Türkiye
Kerimali Akyildiz Recep Tayyip Erdogan University, Türkiye
Dr. Öğr. Üyesi Lamiye YILDIZ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Levent Tumkaya Recep Tayyip Erdogan University, Türkiye
Zihni Acar Yazici Recep Tayyip Erdogan University, Türkiye
Adnan Yilmaz Recep Tayyip Erdogan University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Behavioural Brain Research (Q2) | ||
| Dergi ISSN | 0166-4328 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | |||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-06-2021 |
| Cilt / Sayı / Sayfa | 408 / 1 / 113290–113290 | DOI | 10.1016/j.bbr.2021.113290 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0166432821001789?via%3Dihub | ||
| UAK Araştırma Alanları |
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| Özet |
| It has been established that cisplatin causes neuronal damage and cognitive impairment. However, the mechanism is not sufficiently clear. Apelin-13 is an endogenous peptide with strong neuroprotective effects through the synthesis of neurotrophic factors and suppression of inflammation. The aim of this study was to investigate the role of brain-derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) signaling pathway and the potential inhibitory effects of apelin-13 in the mechanism of cisplatin-induced hippocampal damage and cognitive impairment. Apelin-13 was administered to adult sprague dawley male rats at a dose of 20 nmol/kg every day for 4 weeks, cisplatin was administered at a dose of 5 mg/kg once a week for 4 weeks. The spatial and recognition memory tests of the rats were performed on the 5th week. BDNF and the inflammatory cytokines tumor necrosis factor-α (TNF-α) and ... |
| Anahtar Kelimeler |
| Apelin-13 | BDNF | Cisplatin | Hippocampus | TNF-α |
Science Direct
Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction To be published in: Behavioural Brain Research.
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 8 |
| Web of Science | 35 |
| Scopus | 33 |
| Google Scholar | 44 |