Effect of B-Glucan on acetic acid-induced colitis in rats
Yazarlar (6)
Zeki Özsoy
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret GEVREK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Şeyma ÖZSOY Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Mehmet Fatih DAŞIRAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Gökhan Giray Akgül
Erdinç Yenidoğan
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE (Q4) | ||
| Dergi ISSN | 1940-5901 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2018 |
| Cilt / Sayı / Sayfa | 11 / 8 / 7775–7787 | DOI | – |
| UAK Araştırma Alanları |
Genel Cerrahi
|
||
| Özet |
| Objective: This study aimed to determine the effects of β-Glucan on colitis induced by acetic acid (AA). Methods: A total of 28 Wistar-Albino male rats were divided into four groups. Intrarectal saline were administered in the group 1. AA colitis model was created in the group 2. Intrarectal saline and β-Glucan were administered in the group 3. β-Glucan was given daily after induction of colitis in the group 4. β-Glucan was given by daily gavage for 4 days with 50 mg/kg in the treatment groups. Macroscopically and histologically colon damage was assessed. Biochemically, tumor necrosis factor (TNF) α, interleukin (IL)-1β, IL-6, myeloperoxidase (MPO), malonyldialdehyde (MDA), glutathione (GSH) and superoxid dismutase (SDO) values were measured. Results: There was improvement in the macroscopic and histological damage in the colon, but was not statistically significant (p> 0.05). Biochemically, there was an insignificant difference in MPO, IL-6, TNF α and MDA levels (respectively p= 0.611, p= 0.540, p= 0.065, and p= 0.129, respectively) while a significant decrease in IL-1β, SOD and GSH levels (p= 0.012, p= 0.013, and p< 0.001, respectively). Conclusions: β-Glucan has protective effects in the treatment of ulcerative colitis. |
| Anahtar Kelimeler |
| Ulcerative colitis | beta-Glucan | treatment | rats |
