Synthesis and cytotoxic activity of (4-substituted benzylidene)-(3-phenyl-1,2,4-oxadiazol-5-yl)methylamine
Yazarlar (5)
K. Kucukoglu
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Doç. Dr. Mehtap TUĞRAK SAKARYA Atatürk Üniversitesi, Türkiye
A. Demirtas
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
H. Sakagami
Meikai University, Japonya
Meikai University, Japonya
H. I. Gul
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Pharmaceutical Chemistry Journal (Q4) | ||
| Dergi ISSN | 0091-150X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2016 |
| Cilt / Sayı / Sayfa | 50 / 4 / 234–238 | DOI | 10.1007/s11094-016-1429-7 |
| UAK Araştırma Alanları |
Farmasotik Kimya
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| Özet |
| This work was aimed at the synthesis and investigation of the cytotoxic activity of a series of Schiff bases having (4-substituted-benzylidene)-(3-phenyl-1,2,4-oxadiazol-5-yl)methylamine structure with different electronic natures of substituents in the phenyl ring. Thus, the study was intended to observe the effect of substituents with different electronic properties on the cytotoxic activity. The synthesized series of compounds (OP) were obtained by six-step synthesis with yields ranging from 12.23 to 25.77%. The chemical structures of these compounds were elucidated by H NMR. The cytotoxicity of compounds against human oral squamous cell carcinoma cell lines [Ca9-22 (gum), HSC-2 (mouth), HSC-3 (fluent), HSC-4 (language)] and human oral normal cells [HGF (gum fibroblasts), HPC (pulp cells), and HPLF (periodontal ligament fibroblasts)] was tested by MTT assay. Among the group of six OP compounds, bromo … |
| Anahtar Kelimeler |
| 1,2,4-oxadiazole | cytotoxicity | Gabriel synthesis | Schiff base |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 4 |
| Google Scholar | 6 |