Synthesis and pharmacological effects of novel benzenesulfonamides carrying benzamide moiety as carbonic anhydrase and acetylcholinesterase inhibitors
Yazarlar (4)
Doç. Dr. Mehtap TUĞRAK SAKARYA Atatürk Üniversitesi, Türkiye
Halise Inci Gül Atatürk Üniversitesi, Türkiye
Öğr. Gör. Barış Anil Atatürk Üniversitesi, Türkiye
Ilhami Gülçin Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Turkish Journal of Chemistry (Q4) | ||
| Dergi ISSN | 1300-0527 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 12-2020 |
| Cilt / Sayı / Sayfa | 44 / 6 / 1601–1609 | DOI | 10.3906/kim-2007-37 |
| UAK Araştırma Alanları |
Farmasotik Kimya
|
||
| Özet |
| N-(1-(4-Methoxyphenyl)-3-oxo-3-((4-(N-(substituted) sulfamoyl) phenyl) amino) prop-1-en-1-yl) benzamides 3a-g were designed since sulfonamide and benzamide pharmacophores draw great attention in novel drug design due to their wide range of bioactivities including acetylcholinesterase (AChE) and human carbonic anhydrase I and II (hCA I and hCA II) inhibitory potencies. Structure elucidation of the compounds was carried out by 1H NMR, 13C NMR, and HRMS spectra. In vitro enzyme assays showed that the compounds had significant inhibitory potential against hCA I, hCA II, and AChE enzymes at nanomolar levels. Ki values were in the range of 4.07±0.38-29.70±3.18 nM for hCA I and 10.68±0.98-37.16±7.55 nM for hCA II while Ki values for AChE were in the range of 8.91±1.65-34.02±5.90 nM. The most potent inhibitors 3g (Ki= 4.07±0.38 nM, hCA I), 3c (Ki= 10.68±0.98 nM, hCA II), and 3f (Ki= 8.91±1.65 nM, AChE) can be considered as lead compounds of this study with their promising bioactivity results. Secondary sulfonamides showed promising enzyme inhibitory effects on AChE while primary sulfonamide derivative was generally effective on hCA I and hCA II isoenzymes. |
| Anahtar Kelimeler |
| Acetylcholinesterase | Benzamide | Carbonic anhydrase | Enzyme inhibition | Sulfonamide |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 17 |
| Google Scholar | 25 |