Synthesis and Cytotoxicities of 2-[4-hydroxy-(3,5-bis-aminomethyl)- benzylidene]-indan-1-ones
Yazarlar (3)
Doç. Dr. Mehtap TUĞRAK SAKARYA Atatürk Üniversitesi, Türkiye
Prof. Dr. Halise Inci Gul Atatürk Üniversitesi, Türkiye
Hiroshi Sakagami Meikai University, Japonya
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Letters in Drug Design and Discovery (Q4) | ||
| Dergi ISSN | 1570-1808 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2015 |
| Cilt / Sayı / Sayfa | 12 / 10 / 806–812 | DOI | 10.2174/1570180812666150430002002 |
| Makale Linki | http://dx.doi.org/10.2174/1570180812666150430002002 | ||
| UAK Araştırma Alanları |
Farmasotik Kimya
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| Özet |
| Chalcones and Mannich bases are bioactive compounds and known with their cytotoxicities. α,β-Unsaturated ketones are reported with their alkylating potential to cellular thiols thereby inducing cytotoxicities. In this study; Mannich bases (MT2-MT7), which may generate two additional alkylating centers comparing with starting compound 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1- one MT1, were designed and synthesized expecting the increased cytotoxicities in bis Mannich bases. Their cytotoxicities were tested against Ca9-22, HSC-2, HSC-3, and HSC-4 human oral squamous cell carcinoma as tumour cell lines and HGF, HPC, and HPLF human normal oral cells as non tumour cell lines. Amine parts were changed as N-methylpiperazine (MT2), pyrrolidine (MT3), morpholine (MT4), piperidine (MT5), dimethylamine (MT6), and dipropylamine (MT7). As conclusion, Mannich bases prepared showed higher … |
| Anahtar Kelimeler |
| Bis-Mannich bases | Chalcone analogue | Cytotoxicity | Indan-1-one | Phenol | Synthesis | Tumour selectivity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 17 |
| Google Scholar | 18 |