Synthesis of some acrylophenones with methylpiperazine and evaluation of their cytotoxicities
Yazarlar (3)
Prof. Dr. Halise Inci Gul Atatürk Üniversitesi, Türkiye
Doç. Dr. Mehtap TUĞRAK SAKARYA Atatürk Üniversitesi, Türkiye
Hiroshi Sakagami Meikai University, Japonya
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Enzyme Inhibition and Medicinal Chemistry (Q4) | ||
| Dergi ISSN | 1475-6366 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2016 |
| Cilt / Sayı / Sayfa | 31 / 1 / 147–151 | DOI | 10.3109/14756366.2015.1014474 |
| Makale Linki | http://www.tandfonline.com/doi/full/10.3109/14756366.2015.1014474 | ||
| UAK Araştırma Alanları |
Farmasotik Kimya
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| Özet |
| In this study, the compounds having acrylophenone structure, 1-aryl-2-(N-methylpiperazinomethyl)-2-propen-1-one dihydrochlorides, were synthesized and their chemical structures were identified with 1H NMR, 13C NMR and HRMS spectra. The cytotoxicities of the compounds were tested towards Ca9-22 (human gingival carcinoma), HSC-2 (human oral squamous carcinoma), HSC-3 (human oral squamous carcinoma) and HSC-4 (human oral squamous carcinoma) cell lines as tumor cell lines and HGF (gingival fibroblasts), HPLF (periodontal ligament fibroblasts) and HPC (pulp cells) cell lines as non-tumor cell lines. PSE of the compound TA2, which has a methyl substituent on phenyl ring, pointed out the compound TA2 as a leader compound to be considered. |
| Anahtar Kelimeler |
| Acrylophenone | cytotoxicity | Mannich bases | N-methylpiperazine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 18 |
| Google Scholar | 19 |