Synthesis of some acrylophenones with methylpiperazine and evaluation of their cytotoxicities
Yazarlar (3)
Atatürk Üniversitesi, Türkiye
Doç. Dr. Mehtap TUĞRAK SAKARYA
Atatürk Üniversitesi, Türkiye
Meikai University, Japonya
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Dergi ISSN | 1475-6366 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2016 |
| Cilt No | 31 |
| Sayı | 1 |
| Sayfalar | 147 / 151 |
| DOI Numarası | 10.3109/14756366.2015.1014474 |
| Makale Linki | http://www.tandfonline.com/doi/full/10.3109/14756366.2015.1014474 |
| Özet |
| In this study, the compounds having acrylophenone structure, 1-aryl-2-(N-methylpiperazinomethyl)-2-propen-1-one dihydrochlorides, were synthesized and their chemical structures were identified with 1H NMR, 13C NMR and HRMS spectra. The cytotoxicities of the compounds were tested towards Ca9-22 (human gingival carcinoma), HSC-2 (human oral squamous carcinoma), HSC-3 (human oral squamous carcinoma) and HSC-4 (human oral squamous carcinoma) cell lines as tumor cell lines and HGF (gingival fibroblasts), HPLF (periodontal ligament fibroblasts) and HPC (pulp cells) cell lines as non-tumor cell lines. PSE of the compound TA2, which has a methyl substituent on phenyl ring, pointed out the compound TA2 as a leader compound to be considered. |
| Anahtar Kelimeler |
| Acrylophenone | cytotoxicity | Mannich bases | N-methylpiperazine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 18 |
| Google Scholar | 19 |
| Google Scholar | 19 |