Synthesis and anticancer activities of 1,4-phenylene-bis-N-acetyl- and N-phenylpyrazoline derivatives
Yazarlar (5)
Prof. Dr. Meliha Burcu GÜRDERE
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Çankırı Karatekin Üniversitesi, Türkiye
Prof. Dr. Yakup BUDAK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Mustafa CEYLAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | RESEARCH ON CHEMICAL INTERMEDIATES |
| Dergi ISSN | 0922-6168 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2017 |
| Cilt No | 43 |
| Sayı | 3 |
| Sayfalar | 1277 / 1289 |
| DOI Numarası | 10.1007/s11164-016-2697-2 |
| Özet |
| Novel 1,4-phenylene-bis-N-acetyl- (3a-h) and bis-N-phenylpyrazoline derivatives (4a-h) were obtained by addition of hydrazine hydrate and phenylhydrazine to bis-chalcone derivatives (1a-h) in acetic acid and acetic acid/ethanol for 4 and 8 h in reflux conditions, respectively. The structures of the obtained bis-N-acetylpyrazoline and bis-N-phenylpyrazoline derivatives were characterized by nuclear magnetic resonance (NMR) and infrared (IR) spectroscopic methods and elemental analysis. Compounds 3a-h and 4a-h were investigated to evaluate their anticancer activities against C6 (rat brain tumor cells) and HeLa (human uterus carcinoma) in vitro using a dose-dependent assay from 5 to 100 mu M with 5-fluorouracil (5-FU) as standard anticancer drug. Compound 3a showed higher cell-selective activity compared with 5-FU against HeLa cells. Compounds 3a-h (except 3d) were shown to have better activities … |
| Anahtar Kelimeler |
| Anticancer activity | Bis-N-acetylpyrazolines | Bis-N-biphenylpyrazolines | C6 | HeLa |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 10 |
| Google Scholar | 11 |