Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives
Yazarlar (5)
Prof. Dr. Meliha Burcu GÜRDERE
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Çankırı Karatekin Üniversitesi, Türkiye
Prof. Dr. Yakup BUDAK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Mustafa CEYLAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Turkish Journal of Chemistry |
| Dergi ISSN | 1300-0527 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2017 |
| Cilt No | 41 |
| Sayı | 2 |
| Sayfalar | 263 / 271 |
| DOI Numarası | 10.3906/kim-1603-112 |
| Makale Linki | http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=kim-1603-112 |
| Özet |
| A series of 1,4-phenylene-bis-chalcones 3a 3h were synthesized by the reaction of terephthalaldehyde with substituted arylketones in this study. The novel 1,4-phenylene-bis-pyrimidine-2-amine derivatives 5a 5h were obtained by the addition of guanidine hydrochloride to 1,4-phenylene-bis-chalcone 3a 3h in ethanolic KOH under reflux conditions. The structure of the compounds was explained by means of IR, 1 H NMR, 13 C NMR, and elemental analyses. The anticancer activities of 3a 3h and 5a 5h were investigated against rat brain tumor cells and human uterus carcinoma in vitro. Activity tests were performed as dose-dependent assays at eight concentrations. The positive control was 5- fluorouracil (5-FU). Compounds 3c and 3d were examined and they showed high activities as compared to 5-FU against C6 (rat brain tumor) and HeLa (human uterus carcinoma) cells. The anticancer activity of 5h was better than that of 5-FU at high concentrations cell-selectively against C6 cells. |
| Anahtar Kelimeler |
| 1,4-Phenylene-bis-chalcone | 1,4-phenylene-bis-pyrimidine | HeLa | C6 | anticanceractivity | 5-fluorouracil |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 10 |
| Google Scholar | 12 |