Anti-reflux mucosectomy using a cap-assisted endoscopic mucosal resection method for refractory gastroesophageal disease: a prospective feasibility study
Yazarlar (9)
Prof. Dr. Abdullah Özgür YENİOVA
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Surgical Endoscopy |
| Dergi ISSN | 0930-2794 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2019 |
| Cilt No | 34 |
| Sayı | 3 |
| Sayfalar | 1124 / 1131 |
| DOI Numarası | 10.1007/s00464-019-06859-y |
| Makale Linki | http://link.springer.com/10.1007/s00464-019-06859-y |
| Özet |
| Background and aims: Endoscopic therapy of gastroesophageal reflux disease (GERD) overcomes the “treatment gap” for patients with refractory GERD, who are not willing to go into surgery. We propose an easy and efficient technique that is referred to as anti-reflux mucosectomy (ARMS) using cap-assisted endoscopic mucosal resection (EMR-C) which could be called ARMS-C. This study aimed to investigate the short-term outcomes of ARMS-C in GERD patients. Methods: From December 2016 to February 2018, we performed ARMS-C in 33 patients with pathologic reflux disease and esophageal hypersensitivity. ARMS-C involved endoscopic mucosal resection at the circumference of the esophagogastric junction (EGJ), resulting in narrowing of the hiatal opening after healing. The GERD symptoms, 24-h pH monitoring results, manometry, endoscopy, and EGJ distensibility were compared before and after the procedure. Results: Six months after ARMS-C, 63% of patients discontinued the use of pump inhibitors (PPIs), while 30% patients reduced their PPI dose. The GERD questionnaire scores significantly decreased after ARMS-C, from 11.0 to 6.0 (P < 0.001). The median DeMeester score and acid exposure time based on pH monitoring also improved after ARMS-C. Furthermore, the median flap valve grade and EGJ distensibility decreased from 3.0 to 1.0 (P < 0.001) and from 19.0 to 13.9 (P < 0.001), respectively. Two patients were treated with balloon dilation due to stricture, but no other serious adverse events were encountered. Conclusion: ARMS-C may be an effective and safe treatment method for GERD in terms of short-term outcomes. |
| Anahtar Kelimeler |
| Gastroesophageal reflux disease | Anti-reflux mucosectomy | Short-term outcomes | Cap-assisted endoscopic mucosal resection |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 52 |
| SCOPUS | 58 |