Mannose-binding lectin (MBL) levels in children with Hashimoto’s thyroiditis
Yazarlar (4)
Prof. Dr. Ali GÜL
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
Selçuk Üniversitesi, Türkiye
Prof. Dr. Hacı Ömer ATEŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | İstanbul Kuzey Klinikleri |
| Dergi ISSN | 2148-4902 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | ESCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2023 |
| Cilt No | 10 |
| Sayı | 3 |
| Sayfalar | 353 / 358 |
| DOI Numarası | 10.14744/nci.2022.22058 |
| Makale Linki | http://dx.doi.org/10.14744/nci.2022.22058 |
| Özet |
| OBJECTIVE: Hashimoto’s thyroiditis (HT) was described many years ago, but the etiopathogenesis remains unclear. Mannose- binding lectin (MBL) initiates complement activation in the lectin pathway. We determined MBL levels in children with HT and the associations thereof with thyroid hormone and thyroid autoantibody levels. METHODS: Thirty-nine patients with HT and 41 controls were enrolled from the pediatric outpatient clinics. Subjects were grouped according to their thyroid functions: Euthyroid, marked hypothyroidism and clinical/subclinical hyperthyroidism. MBL levels were compared among these groups. Serum MBL levels of the subjects were determined using MBL Human ELISA kit. RESULTS: Serum MBL levels were studied in serum samples from the 80 subjects (48 (60.0%) females). MBL levels in HT and control groups were 50.787±34.718 and 50.593±44.28 ng/ml (p=0,983), respectively. In HT group, there was no significant difference in MBL levels between thyroid function groups (p=0.869). In addition, gender was not detected as a factor for serum MBL levels. Also we found negative correlation between WBC and serum MBL levels (r=-0.532; p=0.050). Otherwise there was no correlation between TSH, anti-TPO and anti-TG with serum MBL levels. CONCLUSION: MBL levels did not decrease in HT patients. Further research is needed to elucidate more fully any role for MBL in the development of autoimmune thyroid disease. |
| Anahtar Kelimeler |
| Autoimmune disease and hypothyroidism | children | Hashimoto's thyroiditis | mannose binding lectin |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 1 |
| Google Scholar | 1 |