Association Between Trp64arg Polymorphism of the β3 adrenoreceptor Gene and Female Sex in Obese Turkish Children and Adolescents
Yazarlar (6)
Selçuk Üniversitesi, Türkiye
Prof. Dr. Hacı Ömer ATEŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ali GÜL
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Tuba KASAP
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Türkiye
Dr. Öğr. Üyesi Emel ENSARİ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION |
| Dergi ISSN | 2234-8646 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | ESCI ve PubMed |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2019 |
| Cilt No | 22 |
| Sayı | 5 |
| Sayfalar | 460 / 469 |
| DOI Numarası | 10.5223/pghn.2019.22.5.460 |
| Makale Linki | https://pghn.org/DOIx.php?id=10.5223/pghn.2019.22.5.460 |
| Özet |
| The β3-adrenergic receptor () is expressed in visceral adipose tissue and has been speculated to contribute to lipolysis, energy metabolism, and regulation of the metabolic rate. In this study, we aimed to investigate the association of polymorphism of the gene with the sex of children with obesity and related pathologies. The frequency of trp64arg genotype was similar in obese and normal weight children. In obese children, serum lipid, glucose, and insulin levels; homeostasis model assessment of insulin resistance (HOMA-IR) scores; and MS were not different between arg allele carriers (trp64arg) and noncarriers (trp64trp). In 264 obese children, genetic analysis results revealed that the arg allele carriers were significantly higher in girls than in boys (=0.001). In the normal weight group, no statistically significant difference was found between genotypes of boys and girls (=0.771). Trp64arg polymorphism of the gene was not associated with obesity and MS in Turkish children and adolescents. Although no relationships were observed between the genotypes and lipids, glucose/insulin levels, or HOMA-IR, the presence of trp64arg variant was frequent in obese girls, which can lead to weight gain as well as difficulty in losing weight in women. |
| Anahtar Kelimeler |
| Child | Gene polymorphism | Obesity | β3-adrenergic receptor |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 5 |
| Google Scholar | 11 |