Insulin resistance and cardiovascular risk factors in women with PCOS who have normal glucose tolerance test
Yazarlar (8)
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Türker TAŞLIYURT
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Eskişehir Osmangazi Üniversitesi, Türkiye
Doç. Dr. Murat BEYHAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Sakarya Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Gynecological Endocrinology |
| Dergi ISSN | 0951-3590 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2013 |
| Cilt No | 29 |
| Sayı | 2 |
| Sayfalar | 148 / 151 |
| DOI Numarası | 10.3109/09513590.2012.730573 |
| Özet |
| Introduction: We aimed to determine the insulin resistance in women with PCOS patients who have normal oral glucose tolerance test (OGTT) and to evaluate cardiovascular risk by measuring C-reactive protein (CRP) and carotid intimae-media thickness (CIMT). Methods: A total of 34 patients and age and body mass matched 20 healthy control subjects were included to this prospective study. Both of patients and control groups were consisted of normal oral glucose tolerance test. Insulin resistance (IR) was estimated using HOMA-IR method. CRP, lipid and hormone levels were measured. CIMT was measured by Carotid Artery B-Mode ultrasonography. Results: There was no significant difference between patients and controls in BMI, and waist circumference, lipid, TSH, LH, FSH, estradiol, and prolactin levels. Serum insulin, testosterone, DHEAS, ferritin levels and HOMA values were significantly higher in patient group. We found that 64.7% (n = 22/34) patients with PCOS had insulin resistance. Both of CIMT and CRP levels were significantly higher in the PCOS patients had BMI over 25kg/m2. CRP levels was significantly higher in the PCOS patients had waist circumference greater than 80cm. Conclusion: We found insulin resistance in the women with PCOS even if OGTT was normal. Our data were similar to literature, the women with PCOS have increased risk of premature atherosclerosis and metabolic syndrome. © 2013 Informa UK, Ltd. |
| Anahtar Kelimeler |
| Carotid intimae-media thickness | Glucose tolerance test | HOMA | Insulin resistance | Polycystic ovary syndrome |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 22 |
| Google Scholar | 38 |