Investigations on Effects of Titanium Dioxide (TiO2) Nanoparticle in Combination with UV Radiation on Breast and Skin Cancer Cells
Yazarlar (5)
Prof. Dr. Mustafa Tuğfan BİLKAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Zehra Çiçek Sağlık Bilimleri Üniversitesi, Türkiye
Ayşe Gülnihal Canseven Kurşun Gazi University, Faculty Of Medicine, Türkiye
Prof. Dr. Mehmet Özler University Of Health Sciences, Antigua ve Barbuda
Prof. Dr. Meriç Arda Eşmekaya Gazi Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Medical Oncology (Q4) | ||
| Dergi ISSN | 1357-0560 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2022 |
| Cilt / Sayı / Sayfa | 40 / 1 / 60–0 | DOI | 10.1007/s12032-022-01931-5 |
| UAK Araştırma Alanları |
Sosyal, Beşeri ve Idari Bilimler
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| Özet |
| In this study, we have investigated the chemotherapeutic potential of titanium dioxide (TiO2) nanoparticles on skin and breast cancer cells. The cells have treated with a 75 µg/ml concentration of titanium dioxide because it is a recommended dose with proven effectiveness in vitro studies and then the cells were exposed to UV-A radiation. The combined effects of titanium dioxide and UV-A radiation on cell viability, cell cycle, plasma membrane, mitochondrial membrane potentials and apoptotic activity of the cells were investigated. The viability of SK-MEL 30 cells was measured by MTT assay and apoptotic activity of cells was determined by Annexin-V FITC/PI staining. As a result of the research, an increase was observed in the viability of cells treated with 75 µg/ml titanium dioxide concentration, while a significant decrease in cell viability was observed for both cell types when UV-A radiation and TiO2 were applied … |
| Anahtar Kelimeler |
| Breast cancer | Skin cancer | Titanium dioxide nanoparticle | Ultraviolet radiation |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 8 |
| Scopus | 10 |
| Google Scholar | 12 |