Evaluation of Tumor Marker Tests Request In A Hospital Setting
Yazarlar (1)
Doç. Dr. Muzaffer KATAR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale |
| Dergi Adı | International Journal of Medical Biochemistry |
| Dergi ISSN | 2587-2362 Scopus Dergi |
| Dergi Tarandığı Indeksler | TRDizin, ProQuest, CABI, Türk Medline, EBSCO, Crossref, Open Access |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2020 |
| Cilt No | 4 |
| Sayı | 1 |
| Sayfalar | 8 / 13 |
| DOI Numarası | 10.14744/ijmb.2020.46220 |
| Makale Linki | https://internationalbiochemistry.com/jvi.aspx?un=IJMB-46220&volume=4&issue=1 |
| Özet |
| Objectives: Early diagnosis and treatment of oncological disease is extremely important and tumor marker tests area valuable tool; however, requests for testing should not be used in excess or without sufficient cause. The aim of thisstudy was to analyze and evaluate the appropriateness of requests for tumor marker tests at a single hospital.Methods: Tumor marker tests for carcinoembryonic antigen (CEA), cancer antigen (CA) 15-3, CA 19-9, and CA 125 performed by a single biochemistry laboratory between January 1, 2018 and December 31, 2019 were assessed retrospectively. These tumor markers can be used for screening, diagnostic confirmation, estimating prognosis, and monitoringfor recurrence. The departments of internal medicine, gastroenterology, endocrine diseases, chest diseases, generalsurgery, gynecology and obstetrics, and medical oncology were the most common sources of the requests.Results: There were 1420 (40%) requests for CEA, 671 (19%) for CA15-3, 868 (25%) for CA 19-9, and 585 (16%) for CA125 during the study period. A significant difference based on gender was determined in requests for CEA and CA 125(p<0.001 and p=0.033, respectively). In all, 312 (22%) of requests for CEA markers, 202 (30.1%) for CA 15-3, 204 (23.5%)for CA 19-9, and 113 (19.3%) for CA 125 requests were above the reference range. Significant positive correlations weredetermined between age and CEA, CA 15-3, and CA 19-9 tumor markers (r=0.262, p<0.001; r=0.096, p=0.013; r=0.090,p=0.008, respectively). The preliminary diagnoses supporting the requests included non-specific pain, acute vaginitis,anemia, anxiety disorder, dyspepsia, neoplasia, and thyroid disorder.Conclusion: The results of this study suggest that outpatient clinics made an excessive number of tumor markerrequests inconsistent with the preliminary diagnosis. Overutilization of laboratory testing incurs significant costsand affects workload, and may also have other potentially adverse effects on patient care. |
| Anahtar Kelimeler |
| Carcinoembriogenic antigen | oncology | test request | tumor follow-up | tumor markers |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| SCOPUS | 2 |
| TRDizin | 1 |
| Google Scholar | 6 |