Free Oxygen Radicals Associated with Growth in Coeliac Disease
Yazarlar (5)
İstanbul Üniversitesi, Türkiye
Doç. Dr. Muzaffer KATAR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Selçuk Üniversitesi, Türkiye
Doç. Dr. Erhan KARAASLAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Healthmed |
| Dergi ISSN | 1840-2291 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2011 |
| Cilt No | 5 |
| Sayı | 5 |
| Sayfalar | 1008 / 1013 |
| Makale Linki | https://www.researchgate.net/profile/Resul-Yilmaz-2/publication/233756613_Free_Oxygen_Radicals_Associated_with_Growth_in_Coeliac_Disease/links/0912f50ffa11f25570000000/Free-Oxygen-Radicals-Associated-with-Growth-in-Coeliac-Disease.pdf |
| Özet |
| Introduction: Coeliac Disease (CD) is an immune-mediated chronic inflammatory disease of upper small intestine in genetically permanent gluten-sensitive individuals. Oxidative stress was reported to play an important role in the pathogenesis of coeliac disease. The aim of this study was to investigate the frequency of the polimorphisms in the structures of the enzymes SOD and GSH-Px with changing levels depending on increased oxidative stress and whether there is an association with the mutations DQA1* 0501, DQB1* 0201, DRB1* 04 reported frequently in coeliac disease. Methods: This study has investigated SOD and GSH-PX polymorphisms and the frequently reported mutations DQA1* 0501, DQB1* 0201 and DRB1* 04 in the patients with CD. Height and weight measurements of the patients were obtained to evaluate their growth and development, also correlation between polymorphisms SOD and GSH-PX and concerned mutations were investigated.Results: This study involved total 56 cases, 35 female (62.5%) and 21 male (37.5%), with a mean age 6.66±4.18 years. Polymorphisms SOD and GSH-PX were found in homozygote, heterozygote and wild-type patients. At least one of the mutations DQA1* 0501, DQB1* 0201 and DRB1* 04 were found in 41 patients. Conclusion: Although etiology of coeliac disease is not entirely clear, many mechanisms have been suggested. It may be observed that the retardation of growth and development in the patients with coeliac disease may be associated with oxidative stress and decreased antioxidant capacity. |
| Anahtar Kelimeler |
| Coeliac disease | Oxidative stress | Retardation of growth and development |
