Genetic variants of folate metabolism and the risk of multiple sclerosis
Yazarlar (3)
Dr. Öğr. Üyesi Ali Erkan AŞCI
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Neurological Research |
| Dergi ISSN | 0161-6412 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2024 |
| Cilt No | 46 |
| Sayı | 6 |
| Sayfalar | 544 / 552 |
| DOI Numarası | 10.1080/01616412.2024.2337519 |
| Makale Linki | http://dx.doi.org/10.1080/01616412.2024.2337519 |
| Özet |
| Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) of unknown cause. Alterations in one-carbon metabolism have impact in the pathophysiology by genetic susceptibility to MS and increased the risk of MS. The aim of this study was to investigate the contribution of the gene polymorphism on Methylenetetrahydrofolate Reductase (), Methionine Synthase Reductase (), Methionine Synthase ) enzymes and of the essential factors (homocysteine, ; cysteine, ; and vitamin B12, ) in folate metabolism. Eligible MS patients ( = 147) and health controls ( = 127) were participated. The gene polymorphisms were analyzed by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and the levels of plasma and tB12 were measured by Enzyme Linked Immunuabsorbent Assay (ELISA). Our results showed that the levels of and were lower and the levels of were higher in MS compared to controls. The observation of high values in all 3 gene polymorphisms suggests that the transsulfiration pathway of is directed towards formation since the methionine synthesis pathway does not work. We could not find any association with all gene polymorphisms with the risk of MS. The allele of and allele of are risk factors for serum level on MS. As for , serum vitB12 was observed in MS patients with allele. |
| Anahtar Kelimeler |
| Folate metabolism | homocystein | cysteine | VitB12 | MTHFR | MTRR | MTR | gene polymorphism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 3 |
| Google Scholar | 3 |