Caffeic Acid Phenethyl Ester Loaded Electrospun Nanofibers for Wound Dressing Application    
Yazarlar (6)
Seçil Kaya
Duygu Elif Yılmaz
İlkgül Akmayan
Doç. Dr. Özlem EĞRİ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tülin Özbek
Türkiye
Serap Derman
Yıldız Teknik Üniversitesi, Türkiye
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Journal of Pharmaceutical Sciences
Dergi ISSN 0022-3549 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 03-2022
Cilt No 111
Sayı 3
Sayfalar 734 / 742
DOI Numarası 10.1016/j.xphs.2021.09.041
Makale Linki http://dx.doi.org/10.1016/j.xphs.2021.09.041
Özet
Electrospinning is an advantageous method with a wide usage area, which enables the production of materials consisting of nano-thickness fibers. In this study, caffeic acid phenethyl ester (CAPE) molecule was loaded onto the poly(lactic-co-glycolic acid) (PLGA) nanofibers and obtained nanofibers were physicochemically and biologically investigated for the first time in the literature. The existence of CAPE molecules, loaded on PLGA membranes by dropping and spraying methods, was evaluated by a comparative investigation of Fourier-transform infrared (FTIR) spectra and X-Ray diffraction (XRD) patterns. Fiber morphology of the membranes was investigated by scanning electron microscope (SEM). CAPE release and swelling behaviors of the membranes were studied in vitro. The radical scavenging activity of CAPE-loaded wound dressing materials was determined by using an antioxidant assay. The …
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