Caecum location in laboratory rats and mice: an anatomical and radiological study
Yazarlar (7)
Dr. Öğr. Üyesi Murat Uysal Türkiye
Prof. Dr. Serdar Savaş Gül Türkiye
Prof. Dr. Serhat KARAMAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ufuk Taş
Türkiye
Türkiye
Prof. Dr. Hilal IRMAK SAPMAZ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Kürşad Aytekin Giresun Üniversitesi, Türkiye
Prof. Dr. Mehmet Kemal Tümer Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Laboratory Animals (Q1) | ||
| Dergi ISSN | 0023-6772 Dergi Bilgileri (2016) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2016 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 04-07-2016 |
| Cilt / Sayı / Sayfa | 51 / 3 / 245–255 | DOI | 10.1177/0023677216658916 |
| Makale Linki | http://journals.sagepub.com/doi/10.1177/0023677216658916 | ||
| UAK Araştırma Alanları |
Fen Bilimleri ve Matematik
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| Özet |
| Intraperitoneal (i.p.) injection is the most frequently used method for implementing parenteral therapies in rats and mice. Whether the caecum is located in the right caudal quadrant or left caudal quadrant in the abdominal cavity is not clear. For that reason, we have developed a method for identifying the location of the caecum in rats and mice and thus revealed the most reliable location for i.p. injection in these animals. Two hundred Wistar albino rats and 100 BALB/c mice were used. The location of the caecum was determined by revealing the intra-abdominal organs immediately following euthanasia, photographing the organs, and archiving the images. Both digital photographic images and computed tomographic (CT) sections were analysed in terms of caecum morphology and location. In both rats and mice, the caecum was most commonly located on the animal’s left side. It was less frequently located on the right side or in the centre. The caecum was typically comma-shaped, but it was round or S-shaped in some animals. The direction of rotation of the caecum from the basis to the apex was mostly counterclockwise. Additionally, the apex showed a tendency to be evenly centred. This study demonstrated that the caecum was mostly located on the animal’s left side; and for that reason, the most suitable location for i.p. injection in these animals was understood to be the right caudal quadrant. Furthermore, when we compared the CT images and autopsy findings, the caecum did not change location in the abdominal cavity postmortem. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 5 |