In vivo effects of intravenous lipidemulsion on lung tissue in anexperimental model of acutemalathion intoxication
Yazarlar (2)
Dr. Öğr. Üyesi Murat Uysal Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serhat KARAMAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Toxicology and Industrial Health (Q3) | ||
| Dergi ISSN | 0748-2337 Dergi Bilgileri (2018) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-02-2018 |
| Cilt / Sayı / Sayfa | 34 / 2 / 110–118 | DOI | 10.1177/0748233717748080 |
| Makale Linki | http://journals.sagepub.com/doi/10.1177/0748233717748080 | ||
| UAK Araştırma Alanları |
Acil Tıp
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| Özet |
| Malathion can be ingested, inhaled, or absorbed through the skin, but acute toxicity is maximized when administered orally. Intravenous lipid emulsion (ILE) treatment is used as a new therapeutic method in cases of systemic toxicity caused by some lipid soluble agents. This study aimed to examine the potential treatment effect of ILE on rat lung tissue in a toxicokinetic model of malathion exposure. Twenty-one adult Wistar albino rats were randomly divided into three equal groups. The groups were organized as group I (control), group II (malathion), and group III (malathion + ILE treatment). Malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were evaluated in lung tissues. Immunohistochemical and Western blot analyses were performed to determine the bax, bcl-2, and caspase-3 expression levels. Tissue GSH-Px and SOD activities were decreased and MDA levels were increased in the malathion group. ILE administration increased GSH-Px and SOD activity and decreased MDA levels compared to the malathion group. Furthermore, expression of bax, bcl-2, and caspase-3 significantly increased in the malathion group, and ILE infusion reduced these expression levels. The present study revealed that acute oral malathion administration increased oxidative stress and apoptosis in the lung tissue of rats. ILE infusion prevented oxidative stress and decreased the deleterious effects of malathion. Taken together, the findings of our study suggest that lipid emulsion infusion has treatment efficacy on malathion-induced lung toxicity. |
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BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 10 |