Central nervous system toxicity after acute oral formaldehyde exposure in rabbits An experimental study
Yazarlar (8)
Semih Arıcı Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serkan KARAMAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serkan Doğru
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Sevil Çaylı Ankara Yıldırım Beyazıt Üniversitesi, Türkiye
Dr. Öğr. Üyesi Akgül ARICI Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Mustafa Süren Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Tuğba KARAMAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ziya Kaya
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | HUMAN & EXPERIMENTAL TOXICOLOGY (Q4) | ||
| Dergi ISSN | 0960-3271 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2014 |
| Cilt / Sayı / Sayfa | 33 / 11 / 1141–1149 | DOI | 10.1177/0960327113514098 |
| Makale Linki | http://het.sagepub.com/cgi/doi/10.1177/0960327113514098 | ||
| Özet |
| Formaldehyde (FA) is one of the most widely used chemical compounds in industrial field. It is described as toxic, particularly to the nervous system, the urogenital system, and the respiratory tracts. In this study, we determined the effects of acute oral exposure to FA in rabbit brain tissue. A total of 16 rabbits were selected and divided into 2 groups: formaldehyde group (group F) and control group (group C). FA was administered to group F at a rate of 40 mg/kg/day via a nasogastric tube for 5 days. Saline was similarly administered to the eight controls. All the animals were euthanized after 5 days of exposure, and brain tissue samples were collected in 10% neutral formalin and embedded in paraffin. To investigate the effects of FA on the apoptotic process, we examined active caspase-3, Bax, and Bcl-2 immunohistochemical expression and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate … |
| Anahtar Kelimeler |
| Formaldehyde | apoptosis | oral toxicity | glial fibrillary acidic protein | rabbit brain |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 25 |
| Web of Science | 9 |