Short-Term and Long-Term Effects of Dexamethasone on Cognitive Dysfunction Induced by Sevoflurane in Adult Rats
Yazarlar (6)
Prof. Dr. Tuğba KARAMAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serkan KARAMAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serkan Doğru
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Hakan TAPAR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Aynur Şahin Türkiye
Mustafa Süren Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION | ||
| Dergi ISSN | 2149-0937 | ||
| Dergi Tarandığı Indeksler | ESCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2017 |
| Cilt / Sayı / Sayfa | 45 / 3 / 158–163 | DOI | 10.5152/TJAR.2017.98624 |
| Makale Linki | http://jtaics.org/jvi.aspx?pdir=tardplng=engun=TARD-98624 | ||
| Özet |
| Objective Postoperative cognitive dysfunction (POCD) is common after anaesthesia in elderly patients. However, it may appear in patients of all ages. The main pathogenesis of cognitive dysfunction remains unclear, although there is some evidence that brain inflammation may alter cognitive abilities. In the present study, we aim to evaluate short-term and long-term effects of dexamethasone on cognitive dysfunction induced by sevoflurane anaesthesia in adult rats. Methods Seven-month-old 30 male Wistar albino rats were randomised into three groups: sevoflurane group (exposure to sevoflurane), sevoflurane + dexamethasone group (exposure to sevoflurane and dexamethasone injection), and control group (exposure to 100% oxygen). Spatial learning and short-term (7 days after exposure) and long-term (30 days after exposure) memory were evaluated using Morris water maze test. Results Sevoflurane … |
| Anahtar Kelimeler |
| Sevoflurane | dexamethasone | cognitive disorders |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 29 |
| Web of Science | 21 |