Evaluation of effects of repeated sevoflurane exposure on rat testicular tissue and reproductive hormones
Yazarlar (7)
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
İzmir Katip Çelebi Üniversitesi, Türkiye
Yıldırım Beyazıt Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serkan KARAMAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret ERDEMİR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | INHALATION TOXICOLOGY |
| Dergi ISSN | 0895-8378 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SSCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2013 |
| Cilt No | 25 |
| Sayı | 4 |
| Sayfalar | 192 / 198 |
| DOI Numarası | 10.3109/08958378.2013.773109 |
| Makale Linki | http://informahealthcare.com/doi/abs/10.3109/08958378.2013.773109 |
| Özet |
| Evaluation of inhalation anesthetics on sperm and reproductive hormones are extremely important. Investigation of the effects of sevoflurane used as an inhalation anesthetic on sperm morphology and reproductive hormones in rat testes. Forty Wistar-Albino male rats were divided into five groups of eight rats each. The control group received 2 L/min oxygen for seven days, 2 h/day while sevoflurane treatment S1 received 1 minimal alveolar concentration (MAC) sevoflurane + 2 L/min oxygen for seven days, 2 h/day, and sevoflurane S2 received 1 MAC sevoflurane + 2 L/min oxygen for seven days, 2 h/day followed by seven days of no treatment. Sevoflurane treatment S3 received 1 MAC sevoflurane + 2 L/min oxygen for 14 days, 2 h/day and sevoflurane treatment S4 received 1 MAC sevoflurane + 2 L/min oxygen for 14 days, 2 h/day, with no treatment for the following seven days. All rats were examined histologically after experimental procedures. Rat luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), and inhibin levels were measured. Histological injury scores were significantly higher in S2, S3, and S4 receiving sevoflurane in comparison to the control group (p = 0.001, <0.001, and 0.001, respectively). Sperm motility and concentration decreased in S3 and S4 compared to the control group (p = 0.03 and 0.02, respectively). Significant differences were detected among all groups for serum LH, FSH, T, and inhibin serum concentrations (p < 0.05). Testicular and sperm morphology, and reproductive hormones were affected by chronic exposure to sevoflurane. However, more randomized, controlled, and well-designed clinical studies with larger population are needed to confirm of these results. |
| Anahtar Kelimeler |
| FSH | inhibin | LH | sevoflurane | sperm | testis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 17 |
| Google Scholar | 27 |