Sequential VEGF and BMP-2 releasing PLA-PEG-PLA scaffolds for bone tissue engineering: I. Design andin vitrotests
Yazarlar (2)
Prof. Dr. Sinan EĞRİ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Karamanoğlu Mehmetbey Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Artificial Cells, Nanomedicine, and Biotechnology |
| Dergi ISSN | 2169-1401 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2016 |
| Cilt No | 45 |
| Sayı | 2 |
| Sayfalar | 321 / 329 |
| DOI Numarası | 10.3109/21691401.2016.1147454 |
| Makale Linki | https://doi.org/10.3109/21691401.2016.1147454 |
| Özet |
| Biodegradable PLA-PEG-PLA block copolymers were synthesized with desired backbone structures and molecular weights using PEG20000. Rectangular scaffolds were prepared by freeze drying with or without using NaCl particles. Bone morphogenetic protein (BMP)-2 was loaded to the matrix after the scaffold formation for sustained release while vascular endothelial growth factor (VEGF) was loaded within the pores with gelatin solution. VEGF release was quite fast and almost 60% of it was released in 2 d. However, sequential - sustained released was observed for BMP-2 in the following few months. Corporation of VEGF/BMP-2 couple into the scaffolds increased the cell adhesion and proliferation. Neither significant cytotoxicity nor apoptosis/necrosis were observed. |
| Anahtar Kelimeler |
| BMP-2 and VEGF controlled release | Biodegradable/biocompatible | PLA-PEG-PLA block copolymers | bone tissue engineering | freeze drying | in vitro tests | salt leaching | scaffolds |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 37 |