New bimetallic dicyanidoargentate(I)-based coordination compounds:Synthesis, characterization, biological activities and DNA-BSAbinding affinities
Yazarlar (7)
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Yusuf YANAR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Çukurova Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy |
| Dergi ISSN | 1386-1425 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2017 |
| Cilt No | 173 |
| Sayı | 1 |
| Sayfalar | 1007 / 1022 |
| DOI Numarası | 10.1016/j.saa.2016.10.035 |
| Makale Linki | https://www.sciencedirect.com/journal/spectrochimica-acta-part-a-molecular-spectroscopy |
| Özet |
| Four compounds -two (2 and 3) completely new- of composition [Ni(edbea)Ag(CN)] (1), [Cu(edbea)Ag(CN)]·HO (2), [Cd(edbea)Ag(CN)]·HO (3) and [Cd(edbea)] [Ag(CN)]·HO (4) {edbea; 2,2'-(ethylenedioxy)bis (ethylamine)}, were synthesized and characterized using elemental, FT-IR, X-Ray (4), thermal, variable temperature magnetic measurement (1 and 2) and biological techniques. The DNA/BSA binding affinities of 2 and 3 were evaluated by UV-Vis spectrophotometric titrations, ethidium bromide exchange experiments and electrophoretic mobility measurements. Compounds 1 and 4 have previously been characterized and shown to reduce the proliferation and migration of tumor cells. For the sake of clarity, 1 precise mechanism of action on microbial organisms and temperature magnetic measurement were determined. The crystallographic analyses showed that 4 was built up of [Cd(edbea)] cations and [Ag(CN)] anions. Complexes demonstrated a remarkable antibacterial (1-4), antifungal (1-4) and antiproliferative activities (2 and 3) to ten human bacterial pathogens, four plant pathogenic fungi or three tumor cells (HeLa, HT29, and C6), respectively. Therefore, our results strongly confirm that cell proliferation, cell morphology, Bcl-2, P53 changes and apoptosis can be related to the pharmacological effects of the complexes as suitable candidate for clinical trials. |
| Anahtar Kelimeler |
| Dicyanidoargentat(I) | 2,2 '-(ethylenedioxy)bis(ethylamine) | Anticancer activity | Antimicrobial activity | Antifugal activity | Apoptosis |
Science Direct
New bimetallic dicyanidoargentate(I)-based coordination compounds:Synthesis, characterization, biological activities and DNA-BSAbinding affinities
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 14 |
| SCOPUS | 16 |
| Google Scholar | 24 |