In vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase I and II
Yazarlar (6)
Süleyman Demirel Üniversitesi, Türkiye
Düzce Üniversitesi, Türkiye
Prof. Dr. Mustafa CEYLAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Sakarya Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY |
| Dergi ISSN | 2169-1401 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2013 |
| Cilt No | 41 |
| Sayı | 6 |
| Sayfalar | 384 / 388 |
| DOI Numarası | 10.3109/21691401.2012.761226 |
| Makale Linki | http://www.tandfonline.com/doi/full/10.3109/21691401.2012.761226 |
| Özet |
| In this study, 4'-(phenylurenyl/thiourenyl)chalcones (14-25) were prepared from 4'-(phenylurenyl/thiourenyl)acetophenones and benzaldehyde derivatives by Claisen-Schmidt condensation. In vitro inhibition effects of chalcone derivatives on purified carbonic anhydrase I and carbonic anhydrase II were investigated by using the CO2 hydration method of Maren. The result showed that all the synthesized compounds inhibited the CA isoenzymes activity. 18 and 19 were found to be most active (IC50 = 25.41 μM and 23.06 μM) for hCA I, respectively. For hCA II, 24 is the most active compound (IC50 = 14.40 μM). |
| Anahtar Kelimeler |
| carbonic anhydrase | chalcone | urea | thiourea | inhibition | In vitro |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 14 |
| Google Scholar | 23 |