Doxorubicin-loaded mPEG-pPAd-mPEG triblock polymeric nanoparticles for drug delivery systems: Preparation and in vitro evaluation
Yazarlar (4)
Doç. Dr. Nazan GÖKŞEN TOSUN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Seçil ERDEN TAYHAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. İsa GÖKÇE
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Cemil ALKAN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Molecular Structure |
| Dergi ISSN | 0022-2860 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2023 |
| Cilt No | 1291 |
| Sayfalar | 135959 / |
| DOI Numarası | 10.1016/j.molstruc.2023.135959 |
| Makale Linki | http://dx.doi.org/10.1016/j.molstruc.2023.135959 |
| Özet |
| Conventional methods in chemotherapy and radiotherapy do not target tumor sites treating breast cancer. Therefore, they cause some extra adverse effects on healthy tissues and cells, which bring fatal results. In recent applications, drug delivery systems have been used to target tumors directly or their environment indirectly. The new approach has attracted considerable interest due to its promise to overcome breast cancer with little adverse effect. Synthetic or natural polymer shell capsules are generally used to deliver therapeutic agents due to their biocompatibility and biodegradability. Doxorubicin (DOX), a convenient chemotherapeutic agent, was encapsulated using produced monomethyl ether ended poly(ethylene glycol)-poly(propylene adipate)- monomethyl ether ended poly(ethylene glycol) (mPEG-pPAd-mPEG) triblock copolymers in this study. The nanoparticle form of the prepared mPEG-pPAd-mPEG … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 12 |