Green synthesis of silver nanoparticles using Macrolepiota procera extract and investigation of their HSP27, HSP70, and HSP90 inhibitory potentials in human cancer cells
Yazarlar (5)
Doç. Dr. Aykut ÖZGÜR
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Alanya Alaaddin Keykubat Üniversitesi, Türkiye
Doç. Dr. Nazan GÖKŞEN TOSUN
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. İbrahim TÜRKEKUL
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. İsa GÖKÇE
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Informa UK Limited |
| Dergi ISSN | 0272-6351 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2023 |
| Cilt No | 41 |
| Sayı | 3 |
| Sayfalar | 330 / 340 |
| DOI Numarası | 10.1080/02726351.2022.2089303 |
| Makale Linki | http://dx.doi.org/10.1080/02726351.2022.2089303 |
| Özet |
| In this study, silver nanoparticles (AgNPs) were synthesized by a microwave-assisted green chemistry method using a crude extract of Macrolepiota procera mushroom. The synthesized M. procera-AgNPs (MP-AgNPs) were characterized by UV–VIS spectroscopy, fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), dynamic light scattering (DLS) technique, and scanning transmission electron microscopy (S-TEM). The cytotoxic activity of synthesized MP-AgNPs was investigated in human breast cancer (MCF-7), lung cancer (A549), osteosarcoma (Saos-2), and colon cancer (HT-29) cell lines. HSP27, HSP70, and HSP90 inhibitory potential of MP-AgNPs were determined in cancer cells by RT-PCR and Western blotting experiments. To analyze the apoptotic profile of MP-AgNPs in cancer cell lines, the expression levels of apoptotic and anti-apoptotic genes were determined using RT-PCR. The … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 12 |