Estrogen Receptor 1 Gene rs22346939 and rs9340799 Variants are Associated with Major Depressive Disorder and its Clinical Features
Yazarlar (5)
Doç. Dr. Filiz ÖZSOY Tokat State Hospital, Türkiye
Ayse F. Nursal Hitit University, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Meral O. Demir Cevdet Aykan State Hospital, Türkiye
Serbulent Yigit Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Current Neurovascular Research (Q4) | ||
| Dergi ISSN | 1567-2026 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2021 |
| Cilt / Sayı / Sayfa | 18 / 1 / 12–19 | DOI | 10.2174/1567202618666210531122239 |
| Makale Linki | http://dx.doi.org/10.2174/1567202618666210531122239 | ||
| Özet |
| Objective Major Depressive Disorder (MDD) is a major health problem worldwide. Estrogen interacts with the central nervous system and has been shown to affect anxiety and depressive behavior. Estrogen mediates its effects by connecting its receptors, estrogen receptors 1 and 2. The purpose of this case-control study was to clarify the association between MDD risk and estrogen receptor 1 (ESR1) gene variants. Methods This study included 245 individuals (125 MDD patients and 120 healthy controls). Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) technics were used for genotypingESR1XbaII (rs9340799) and PvuII (rs22346939) variants. Results There were statistically significant differences between the groups in terms of genotype frequencies of the ESR1PvuII (-397 T > C) variant (p = 0.049) but not for the XbaII (-351 A > G) variant (p > 0.05). However, a … |
| Anahtar Kelimeler |
| Estrogen receptor 1 | Major depressive disorder | PCR-RFLP | Rs22346939 | Rs9340799 | Variant |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 10 |
| Web of Science | 6 |