The Impact of PER3 VNTR Polymorphism on the Development of Schizophrenia in a Turkish Population
Yazarlar (5)
Filiz Ozsoy Tokat State Hospital, Türkiye
Serbülent Yiğit Ondokuz Mayıs Üniversitesi, Türkiye
Ayşe Feyda Nursal Hitit Üniversitesi, Türkiye
Muberra Kulu
Tokat Mental Health And Diseases Hospital, Türkiye
Tokat Mental Health And Diseases Hospital, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Cytology and Genetics (Q4) | ||
| Dergi ISSN | 0095-4527 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2021 |
| Cilt / Sayı / Sayfa | 55 / 2 / 188–193 | DOI | 10.3103/S0095452721020109 |
| Makale Linki | http://dx.doi.org/10.3103/s0095452721020109 | ||
| Özet |
| Introduction Up to 80% of patients who suffer from schizophrenia have sleep impairments, which affect physical and mental health, as well as quality of life. Several tandem repeat polymorphisms (VNTRs) in the Period 3 (Per3) gene have been associated with heritable sleep and circadian variables. The purpose of this study is to investigate the relationship between the VNTR variant of the PER3 gene and genetic predisposition of schizophrenia in a Turkish population. Method Blood samples were taken from 100 patients with schizophrenia, and from 100 normal controls who are age and sex-matched. PER3 genotyping was performed on DNA by polymerase chain reaction (PCR) using specific primers. Results For the PER3 VNTR polymorphism, we found no significant differences in the genotype distribution and allele frequency, between the schizophrenia and control groups. No association was noted between … |
| Anahtar Kelimeler |
| gene | PCR | Period 3 | polymorphism | Schizophrenia | VNTR |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 4 |
| Scopus | 2 |
| Web of Science | 3 |