Effect of AUTS2 gene rs6943555 variant in male patients with schizophrenia in a Turkish population
Yazarlar (4)
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serbülent Yiğit Ondokuz Mayıs Üniversitesi, Türkiye
Muberra Kulu
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | GENE (Q4) | ||
| Dergi ISSN | 0378-1119 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2020 |
| Cilt / Sayı / Sayfa | 756 / 0 / 144913–0 | DOI | 10.1016/j.gene.2020.144913 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0378111920305825 | ||
| Özet |
| Schizophrenia is a severe brain disease seen all over the world. There are studies showing that activator of transcription and developmental regulator AUTS2 (AUTS2) gene is involved in the predisposition to schizophrenia. In this study, we aimed to analyze the correlation between rs6943555 variant of AUTS2 gene and schizophrenia in a Turkish population. This study include 100 schizophrenia patients and 152 unrelated healthy controls. The AUTS2 genotypes were determined by the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) tests. Chi-square and Anova tests were used for statistical analyses. According to results, although the A allele frequency was higher in schizophrenia patients, we didn’t detect statistically significant correlation between schizophrenia and the AUTS2 gene rs6943555 variant (p = 0.057). However after adjusting for gender, significant effects of … |
| Anahtar Kelimeler |
| AUTS2 | Male schizophrenia | Rs6943555 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 13 |
| Web of Science | 6 |