Impact of Endothelial NOS VNTR variant on suspectibility to diabetic neuropathy and type 2 diabetes mellitus
Yazarlar (10)
Serbülent Yiğit Ondokuz Mayıs Üniversitesi, Türkiye
Ayşe Feyda Nursal Hitit Üniversitesi, Türkiye
Dr. Öğr. Üyesi Süheyla UZUN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Hüsniye Rüstemoğlu
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Payam Amiri Dashatan
Faculty Of Medicine, Türkiye
Faculty Of Medicine, Türkiye
Hüseyin Soylu Ondokuz Mayis Üniversitesi, Türkiye
Ayşegül Atmaca Ondokuz Mayis Üniversitesi, Türkiye
Aydın Rüstemoğlu Aksaray Üniversitesi, Türkiye
Nilüfer Kuruca Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Current Neurovascular Research (Q4) | ||
| Dergi ISSN | 1567-2026 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2020 |
| Cilt / Sayı / Sayfa | 17 / 5 / 700–705 | DOI | 10.2174/1567202617999201214230147 |
| Makale Linki | http://dx.doi.org/10.2174/1567202617999201214230147 | ||
| Özet |
| Purpose The aim of this study was to evaluate whether the VNTR intron 4b/4a variant in the eNOS gene is associated with type 2 diabetes mellitus (T2DM) and DPN. Methods A total of 598 subjects were enrolled in the study. eNOS VNTR 4b/4a variant was genotyped by polymerase chain reaction (PCR) method. Results eNOS VNTR intron 4b/4b genotype and b allele increased in patients with both DPN and T2DM compared healthy controls (p=0.0005, OR:1.94, p= 0.000002, OR:4.10, respectively). 4a/4b genotype was more prevalent in controls than in DPN and T2DM patients (p=0.00008, OR:0.46; p=0.000004, OR:0.24, respectively). eNOS VNTR b allele was more common in DPN patients and T2DM patients compared with controls (p=0.007, p=0.00002, respectively). Conclusion The eNOS VNTR “4b/4b” homozygous genotype and hence “4b”allele as a genetic risk factor for T2DM and DPN, which may … |
| Anahtar Kelimeler |
| Diabetes mellitus | Diabetic peripheral neuropathy | Endothelial NOS VNTR variant | Genotype | Hyperglycemia | Peripheral nerve |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 7 |
| Scopus | 2 |
| Web of Science | 5 |