Influence of the MIF polymorphism −173G C on Turkish postmenopausal women with osteoporosis
    
Yazarlar (8)
Prof. Dr. Asker Zeki ÖZSOY Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
S. Tural
Ondokuz Mayis Üniversitesi, Türkiye
S. Yigit
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
N. Kara
Ondokuz Mayis Üniversitesi, Türkiye
G. Alayli
Ondokuz Mayis Üniversitesi, Türkiye
M. K. Tumer
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
O. Kuru
Ondokuz Mayis Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Zeitschrift Fur Rheumatologie (Q4)
Dergi ISSN 0340-1855 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce Basım Tarihi 09-2018
Cilt / Sayı / Sayfa 77 / 7 / 629–632 DOI 10.1007/s00393-017-0382-5
Makale Linki http://link.springer.com/10.1007/s00393-017-0382-5
Özet
BackgroundMIF, a proinflammatory cytokine, contributes to the pathogenesis of acute, chronic, and autoimmune inflammatory disorders and balances the suppressive effect of glucocorticoids on the immune system. There is an interaction between bone metabolism and the immune system via the production of cytokines. We aimed to analyze the relationship between the MIF gene −173G > C promoter polymorphism and osteoporosis.MethodsIn this case–control study performed in a university hospital, 286 samples (136 women with osteoporosis and 150 healthy age-matched controls) participated. The polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) assay was used to genotype the MIF gene polymorphism. The alleles and genotypes frequencies of patients and controls were compared using the χ2 test.ResultsThe genotype frequencies of MIF gene −173G > C polymorphism …
Anahtar Kelimeler
Genetic susceptibility | MIF | Osteoporosis | Polymorphism
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Google Scholar 7
Scopus 1
Web of Science 3
Influence of the MIF polymorphism −173G C on Turkish postmenopausal women with osteoporosis

Paylaş