MTHFR gene C677T and A1298C variants are associated with FMF risk in a Turkish cohort
Yazarlar (5)
Ayşe Feyda Nursal Hitit Üniversitesi, Türkiye
Süheyla Kaya Tokat Gaziosmapasa University, Türkiye
Özlem Sezer Samsun Training And Research Hospital, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serbülent Yiğit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of Clinical Laboratory Analysis (Q4) | ||
| Dergi ISSN | 0887-8013 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2018 |
| Cilt / Sayı / Sayfa | 32 / 2 / 22259–0 | DOI | 10.1002/jcla.22259 |
| Makale Linki | http://doi.wiley.com/10.1002/jcla.22259 | ||
| Özet |
| Background Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in homocysteine (Hcy) metabolism. We aimed to evaluate a possible relationship between MTHFR gene C677T (rs 1801133), A1298C (rs 1801131) variants and susceptibility to FMF in a Turkish cohort. Material‐Methods This case‐control study included 198 Turkish FMF patients and 100 healthy subjects as controls. MTHFR C677T and A1298C were analyzed by polymerase chain reaction (PCR)‐restriction fragment length polymorphism (RFLP) methods. Results The genotype distribution and allele frequency of the MTHFR C677T were statistically different between the patients and the control group (P=.006, P=.001, respectively). The frequency of the TT genotype and T allele of MTHFR C677T was significantly higher in the patients than in the controls. The genotype distribution of MTHFR A1298C variant did not show any … |
| Anahtar Kelimeler |
| FMF | homocystein | methylenetetrahydrofolate reductase | variant |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 8 |
| Web of Science | 4 |