Association of the MTHFR Gene C677T Polymorphism with Breast Cancer in a Turkish Population
Yazarlar (5)
Emir F. Kaya
Alacam State Hospital, Türkiye
Alacam State Hospital, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ali N. Ulusoy
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Cihangir Özaslan
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Nurten Kara
Onkology Research Hospital, Türkiye
Onkology Research Hospital, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Oncology Research and Treatment (Q4) | ||
| Dergi ISSN | 2296-5270 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2016 |
| Cilt / Sayı / Sayfa | 39 / 9 / 534–538 | DOI | 10.1159/000448084 |
| Makale Linki | http://www.karger.com/?doi=10.1159/000448084 | ||
| Özet |
| Background: Breast cancer is the most common cancer among women. 1 in every 8 women in the United States have a lifetime risk of getting breast cancer. MTHFR is a key enzyme that regulates the folate metabolism which has an important role in DNA synthesis, repair, and methylation. The aim of the current study was to analyze the association between the MTHFR gene C677T (Ala222Val, rs1801133) polymorphism and breast cancer. Patients and Methods: 199 breast cancer patients and 195 healthy controls were included in this study. The MTHFR gene C677T polymorphism was analyzed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) methods. A meta-analysis including 707 breast cancer patients and 880 controls from Turkish populations was also carried out. Statistical analyses were performed using the χ2 test. Results: No statistically … |
| Anahtar Kelimeler |
| Breast cancer | C677T | MTHFR | Turkish population |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 25 |
| Scopus | 4 |
| Web of Science | 16 |