Relationship between manganese superoxide dismutase (MnSODAla-9Val) and glutathione peroxidase (GPx1 Pro 197 Leu) gene polymorphisms and alopecia areata
Yazarlar (8)
Göknur Kalkan Ankara Yildirim Beyazit University, Türkiye
Havva Yıldız Seçkin Tokat Gaziosmanpaşa Üniversitesi, Türkiye
İsmail Benli Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ali Akbaş Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Yalçın Baş
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
İlknur Bütün Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Hüseyin Özyurt
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | International Journal of Clinical and Experimental Medicine (Q4) | ||
| Dergi ISSN | 1940-5901 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2015 |
| Cilt / Sayı / Sayfa | 8 / 11 / 21533–21540 | DOI | – |
| Özet |
| Objective The role of the oxidative stress in alopecia areata (AA) has been studied by several researchers in a few studies with conflicting results. These results suggested that lipid peroxidation and alterations in the oxidant-antioxidant enzymatic system may play a role in the pathogenesis of AA. Therefore, we aimed to examine the possible associations between the MnSOD Ala-9Val and GPx1 Pro 198 Leu polymorphisms and AA susceptibility and disease progression in Turkish population. Methods The study group consisted of 119 unrelated patients with AA and 104 unrelated healthy controls with no scalp lesions in their personal history or on clinical examination. Genotyping was performed to identify MnSOD Ala-9Val and GPx1 Pro 198 Leu polymorphisms by a method based on PCR amplification and detection of polymorphisms with hybridization probes labeled with fluorescent dyes. Genotype and allele … |
| Anahtar Kelimeler |
| Alopecia areata | GPx1 Pro 198 Leu | MnSOD Ala-9Val | Polymorphism |
