Clinical Significance of NCOA5 Gene rs2903908 polymorphism in Behçet’s Disease
Yazarlar (8)
Aydin Rustemoglu Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Esraerkol Inal Süleyman Demirel University, Faculty Of Medicine, Türkiye
Prof. Dr. Ahmet İNANIR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Duygu Ekinci Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ulker Gul
Akdeniz Üniversitesi, Türkiye
Akdeniz Üniversitesi, Türkiye
Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Omer Ates Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Excli Journal (Q4) | ||
| Dergi ISSN | 1611-2156 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2017 |
| Cilt / Sayı / Sayfa | 16 / 1 / 609–617 | DOI | 10.17179/excli2017-189 |
| Özet |
| Behçet's disease (BD) is an autoimmune multisystemic disease. The precise etiology of BD is not fully understood; however, it is thought that interactions between genetic and environmental factors play an essential role in its pathogenesis. The nuclear receptor coactivator-5 (NCOA5) gene encodes a coregulator for nuclear receptor subfamily 1 group D member 2 (NR1D2) and estrogen receptor 1 and 2 (ESR1 and ESR2). Also, the NCOA5 gene insufficiency leads to an elevated expression of IL-6, and increased levels of IL-6 were found to be related to the pathogenesis of BD. In this study, we aimed to clarify the impact of the NCOA5 rs2903908 polymorphism on susceptibility and clinical findings of BD. This study included 671 participants (300 BD patients and 371 healthy controls). The analyses of NCOA5 rs2903908 polymorphism was performed by using the TaqMan allelic discrimination assay. The frequency of … |
| Anahtar Kelimeler |
| Behçet’s disease | NCOA5 | rs2903908 | Uveitis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 14 |
| Web of Science | 8 |