Analysis of Manganese Superoxide Dismutase and Glutathione Peroxidase 1 Gene Polymorphisms in Vitiligo
Yazarlar (7)
Havva Yıldız Seçkin Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Göknur Kalkan Ankara Yildirim Beyazit University, Türkiye
İlknur Bütün Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ali Akbaş Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Yalçın Baş
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
İsmail Benli Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biochemical Genetics (Q4) | ||
| Dergi ISSN | 0006-2928 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2016 |
| Cilt / Sayı / Sayfa | 54 / 4 / 438–447 | DOI | 10.1007/s10528-016-9730-4 |
| Makale Linki | http://link.springer.com/10.1007/s10528-016-9730-4 | ||
| Özet |
| Vitiligo is a hereditary/acquired progressive pigmentation disorder characterized by discoloration of skin as a result of melanocyte dysfunction. Recent studies have proposed that oxidant/antioxidant status plays an important role in vitiligo pathogenesis because of the toxic effects on melanocytes. In this study, we aimed to investigate possible associations of MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms with vitiligo with in Turkish population. The study group consists of 57 patients with vitiligo and 69 healthy controls. Genotyping is performed to identify MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms. The method used for genotyping was based on the PCR amplification and detection of polymorphisms by hybridization probes labeled with fluorescent dyes. Both the genotype and allele frequencies of MnSOD Ala-9Val (p = 0.817 and p = 0.553, respectively) and GPx1 Pro198Leu polymorphisms (p = 0 … |
| Anahtar Kelimeler |
| GPx1 | MnSOD | Polymorphism | Vitiligo |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 3 |
| Scopus | 1 |
| Web of Science | 2 |