The Evaluation of IL6 and ESR1 Gene Polymorphisms in Primary Dysmenorrhea
Yazarlar (6)
Prof. Dr. Asker Zeki ÖZSOY Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Bulent Cakmak Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Mehmet Can Nacar Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Hatice Yilmaz Dogru
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Immunological Investigations (Q4) | ||
| Dergi ISSN | 0882-0139 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2016 |
| Cilt / Sayı / Sayfa | 45 / 1 / 75–86 | DOI | 10.3109/08820139.2015.1113426 |
| Makale Linki | http://www.tandfonline.com/doi/full/10.3109/08820139.2015.1113426 | ||
| Özet |
| Primary dysmenorrhea is the most common gynecological complaint with painful menstrual cramps in pelvis without any pathology. It affects about half of menstruating women, and it causes significant disruption in quality of life. We investigated the association between IL6 gene promoter and ESR1 gene XbaI and PvuII polymorphisms and primary dysmenorrhea. In this case–control study, 152 unrelated young women with primary dysmenorrhea and 150 unrelated healthy age-matched controls participated. Genomic DNA was isolated and IL6 and ESR1 gene polymorphisms were genotyped using PCR-based RFLP assay. The distribution of genotype and allele frequencies of IL6 gene promoter and ESR1 gene XbaI polymorphisms were not statistically different between patients and controls (p > 0.05). However, the genotype and allele frequencies of ESR1 gene PvuII polymorphism showed statistically significant … |
| Anahtar Kelimeler |
| ESR1 | genetic susceptibility | IL6 | polymorphism | primary dysmenorrhea |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 24 |
| Scopus | 5 |
| Web of Science | 13 |