Angiotensin converting enzyme and methylenetetrahydrofolate reductase gene variations in fibromyalgia syndrome
Yazarlar (6)
Ahmet İnanır Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serbülent Yiğit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Akın Tekcan Kırşehir Ahi Evran Üniversitesi, Türkiye
Ferda Alpaslan Pınarlı
Sema İnanır
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | GENE (Q4) | ||
| Dergi ISSN | 0378-1119 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2015 |
| Cilt / Sayı / Sayfa | 564 / 2 / 188–192 | DOI | – |
| Özet |
| ObjectiveFibromyalgia syndrome (FM) is a common disease characterized by generalized body pain, sensitivity in certain physical areas (sensitive points), lowered pain threshold, sleep disorder, and fatigue. The study aimed to determine the effects ACE I/D and MTHFR C677T gene polymorphisms in Turkish patients with FM and evaluate if there was an association with clinical features.MethodsThis study included 200 FM patients and 190 healthy controls recruited from the department of Physical Medicine and Rehabilitation at Gaziosmanpasa University in Tokat, Turkey. ACE I/D polymorphism genotypes were determined by using polymerase chain reaction (PCR) by specific primers. The MTHFR C677T mutation was analyzed by PCR-based restriction fragment length polymorphism (RFLP) methods.ResultsWe found a statistically significant relation between ACE polymorphism and FM (p < 0.001, OR: 1.71, 95 … |
| Anahtar Kelimeler |
