Association of MEFV Gene Mutations With Rheumatoid Factor Levels in Patients With Rheumatoid Arthritis
Yazarlar (5)
Ahmet İnanır Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serbülent Yiğit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Şaban Tekin Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Aydın Rüstemoğlu Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Investigative Medicine (Q4) | ||
| Dergi ISSN | 1708-8267 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2013 |
| Cilt / Sayı / Sayfa | 61 / 3 / 593–596 | DOI | 10.2310/JIM.0b013e318280a96e |
| Özet |
| PurposeRheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting the joints. Arthritis disorders are associated with mutations of the Mediterranean fever (MEFV) gene. This gene has already been identified as being responsible for familial Mediterranean fever. The aim of this study was to explore the frequency and clinical significance of MEFV gene mutations in a cohort of Turkish patients with RA.MethodsThe study included 101 patients with RA and 110 healthy controls. Genomic DNA was isolated and genotyped using polymerase chain reaction and restriction fragment length polymorphism for the 5 MEFV gene mutations (M694V, M680I, V726A, E148Q, and P369S).ResultsCarrier rates of MEFV gene mutations were 31 (30.7%) of 101 and 26 (23.6%) of 110 in the RA and healthy control groups, respectively (P > 0.05; odds ratio, 1.4; 95% CI, 0.77–2.65). Whereas deformed joint count was … |
| Anahtar Kelimeler |
| Autoimmune disease | MEFV gene | Mutation | Rheumatoid arthritis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 21 |
| Scopus | 1 |
| Web of Science | 11 |