Association Between 1603C T Polymorphism of DBH Gene and Bipolar Disorder in a Turkish Population
Yazarlar (5)
Omer Ates Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Feryal Cam Celikel Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serap Erdogan Taycan Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Saime Sezer
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Gene (Q4) | ||
| Dergi ISSN | 0378-1119 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2013 |
| Cilt / Sayı / Sayfa | 519 / 2 / 356–359 | DOI | 10.1016/j.gene.2013.01.031 |
| Özet |
| OBJECTIVES Dopamine-β-hydroxylase (DBH) is the enzyme responsible for the conversion of dopamine (DA) to norepinephrine (NE, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems. Bipolar disorder is a major psychiatric disorder. The present study was designed to explore the associations of polymorphisms of DBH gene in Turkish patients with bipolar disorder. METHODS −1021C>T (rs1611115) polymorphism in promoter region, 444G>A (rs1108580) polymorphism in exon 2 and 1603C>T (rs6271; C535R) polymorphism in exon11 of DBH gene were analyzed in 106 patients with bipolar disorder and 106 healthy subjects by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. RESULTS The results showed statistically significant associations for genotypic and allelic distribution between the 1603C>T polymorphism … |
| Anahtar Kelimeler |
| Association study | Bipolar disorder | DBH | Genetic susceptibility | Polymorphism |
Science Direct
Association Between 1603C T Polymorphism of DBH Gene and Bipolar Disorder in a Turkish Population
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 26 |
| Scopus | 6 |
| Web of Science | 18 |