The association between Interleukin IL 4 gene intron 3 VNTR polymorphism and alopecia areata AA in Turkish population
Yazarlar (7)
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Afyon Kocatepe Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Gene |
| Dergi ISSN | 0378-1119 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2013 |
| Cilt No | 527 |
| Sayı | 2 |
| Sayfalar | 565 / 569 |
| DOI Numarası | 10.1016/j.gene.2013.05.086 |
| Özet |
| Objective: Alopecia areata (AA) is hypothesized to be an organ-specific autoimmune disease of hair follicles mediated by T cells. As immunological and genetic factors have been implicated in the pathogenesis of AA, the purpose of the present study was to investigate possible associations between the functional Interleukin (IL)-4 gene intron 3 VNTR polymorphism and AA susceptibility and disease progression in Turkish population. Methods: The study group consisted of 116 unrelated patients with AA and 125 unrelated healthy controls. Genomic DNA was isolated and IL-4 gene 70. bp VNTR polymorphism determined by using polymerase chain reaction (PCR) with specific primers. Results: No association was observed between AA patients and controls according to genotype distribution (p= 0.051). The allele distribution of IL-4 gene intron 3 VNTR polymorphism was statistically different between AA patients and control group (p= 0.026). The frequency of P1 allele in patients was significantly higher than that in the control group. When the P2P2 genotype was compared with P1P2. +. P1P1 genotypes, a statistically significant difference was observed between patients and controls (p= 0.036). Intron 3 VNTR polymorphism in the IL-4 gene was found to be associated with AA susceptibility in Turkish population. Conclusion: The results suggest that IL-4 VNTR polymorphism in the intron 3 region may be a risk factor for the development of AA among Turkish population. This is the first to report that intron 3 VNTR polymorphism in the IL-4 gene is associated with AA susceptibility. © 2013 Elsevier B.V. |
| Anahtar Kelimeler |
| Alopecia | Alopecia areata | Genetic skin disorders | IL-4 | Polymorphism |
Science Direct
The association between Interleukin IL 4 gene intron 3 VNTR polymorphism and alopecia areata AA in Turkish population
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 37 |
| SCOPUS | 43 |
| Google Scholar | 62 |