The importance of association between angiotensin converting enzyme ACE Gene I D polymorphism and diabetic peripheral neuropathy
Yazarlar (4)
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Gene |
| Dergi ISSN | 0378-1119 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2014 |
| Cilt No | 530 |
| Sayı | 2 |
| Sayfalar | 253 / 256 |
| DOI Numarası | 10.1016/j.gene.2013.07.051 |
| Özet |
| Background: Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus (DM) due to decreasing quality of life. In the present study, it is aimed to evaluate angiotensin-converting enzyme (ACE) Gene I/D polymorphism in Turkish population. Materials and methods: Two hundred and thirty-five DPN patients and two hundred and eighty-one controls were enrolled in this study. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) analyses for the ACE gene I/D polymorphism. Results: Baseline characteristics of the DPN patients according to ACE genotypes were similar, except for history of hypertension. The frequency of II genotype was significantly higher in patients with positive history of hypertension than the patients with negative history of hypertension (p. = 0.013). DD genotype of I/D polymorphism was found to be a susceptibility factor for DPN in homozygous form (p. = 0.032). According to allele frequencies, D allele of I/D polymorphism was found to be a susceptibility factor for DPN (p. = 0.031). Conclusion: ACE gene I/D polymorphism may research in DM patients to determine genetic predisposition for DPN. It can be useful for taking early measures and avoiding DPN in a Turkish population. © 2013 Elsevier B.V. |
| Anahtar Kelimeler |
| Angiotensin-converting enzyme | Bp | Diabetic peripheral neuropathy | Gene Polymorphism |
Science Direct
The importance of association between angiotensin converting enzyme ACE Gene I D polymorphism and diabetic peripheral neuropathy
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 22 |
| SCOPUS | 21 |
| Google Scholar | 33 |